Problems resulting from interbreeding in cats and dogs vary significantly as most owners allow the to litter reach the maturity age allowing them to mate with their original parent causing many congenital diseases which most of them are fatal as congenital acute renal failure, congenital acute liver failure(Neonatal liver failure), Portosystemic shunt(PSS), congenital Megacolon, congenital Megaoesohohagus(good prognosis with modified lifestyle) and other congenital nerve and brain conditions.

Try to choose different bloodline mates for your pet from the same breed to avoid such conditions.